NMS-1286937

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For R&D use only.

Catalog NO.：A896452
CAS No. : 1034616-18-6
Molecular Formula：C₂₄H₂₇F₃N₈O₃
Molecular Weight： 532.52

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Product Details

CAS Number	1034616-18-6	Appearance
Catalog Number	A896452	MDL Number	MFCD26793840
Molecular Formula	C₂₄H₂₇F₃N₈O₃	Molecular Weight	532.52
Boiling Point		Melting Point
Flash Point		Density
Synonyms	CHEBI:1217805; NMS-P937; 1-(2-Hydroxyethyl)-8-[[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino]-4,5-Dihydropyrimido[5,4-G]indazole-3-Carboxamide; CHEMBL1738758; SureCN1228019; 1-(2-hydroxy-ethyl)-8-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide; UNII-67RM91WDHQ; AMX10197;1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H302-H315-H319-H335	Class
Precautionary Statements	P261-P305+P351+P338	Packing Group

Description

NMS1286937, also know as NMS-P937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.

P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use

P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/…/combustible materials.
P221	Take any precaution to avoid mixing with combustibles/…
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted with …
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool.
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/…/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.

P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320	Specific treatment is urgent (see … on this label).
P321	Specific treatment (see … on this label).
P322	Specific measures (see …on this label).
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378	Use … for extinction.
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire: Use … for extinction.
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371	In case of major fire and large quantities:
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P401	Store …
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/… container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411	Store at temperatures not exceeding … oC/…oF.
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413	Store bulk masses greater than … kg/…lbs at temperatures not exceeding … oC/…oF.
P420	Store away from other materials.
P422	Store contents under …
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Store at temperatures not exceeding … oC/…oF. Keep cool.

P501	Dispose of contents/container to..…
P502	Refer to manufacturer/supplier for information on recovery/recycling

NMS-1286937

Product Details

Safety

Description

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
H202	Explosives (Div 1.2)
H203	Explosives (Div 1.3)
H204	Explosives (Div 1.4)
H205	Explosives （Div 1.5)
H220	Flammable gases (Category 1)
H221	Flammable gases (Category 2)
H222	Flammable aerosols (Category 1)
H223	Flammable aerosols (Category 2)
H224	Flammable liquids (Category 1)
H225	Flammable liquids (Category 2)
H226	Flammable liquids (Category 3)
H227	Flammable liquids (Category 4)
H228	Flammable solids (Category 1)
H240	Self-reactive substances and mixtures; and Organic peroxides (Type A)
H241	Self-reactive substances and mixtures; and Organic peroxides (Type B)
H242	Self-reactive substances and mixtures; and Organic peroxides (Type C. D.)
H250	Pyrophoric liquids; Pyrorophoric solids (Category 1)
H251	Self-heating substances and mixtures (Category 1)
H252	Self-heating substances and mixtures (Category 2)
H260	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 1)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 2)
H261	Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases (Category 3)
H270	Oxidising gases (Category 1)
H271	Oxidising liquids;Oxidising solids (Category 1)
H272	Oxidising liquids;Oxidising solids (Category 2)
H280	Gases under pressure Compressed gas Liquefied gas Dissolved gas
H281	Gases under pressure Refrigerated liquefied gas
H290	Corrosive to Metals (Category 1)

H300	Acute toxicity,oral (Category 1, 2)
H301	Acute toxicity,oral (Category 3)
H302	Acute toxicity,oral (Category 4)
H303	Acute toxicity,oral (Category 5)
H304	Aspiration hazard (Category 1)
H305	Aspiration hazard (Category 2)
H310	Acute toxicity,dermal (Category 1, 2)
H311	Acute toxicity,dermal (Category 3)
H312	Acute toxicity,dermal (Category 4)
H313	Acute toxicity,dermal (Category 5)
H314	Skin corrosion/irritation (Category 1A, B, C)
H315	Skin corrosion/irritation (Category 2)
H316	Skin corrosion/irritation (Category 3)
H317	Sensitisation, Skin (Category 1)
H318	Serious eye damage/eye irritation (Category 1)
H319	Serious eye damage/eye irritation (Category 2A)
H320	Serious eye damage/eye irritation (Category 2B)
H330	Acute toxicity,inhalation (Category 1, 2)
H331	Acute toxicity,inhalation (Category 3)
H332	Acute toxicity,inhalation (Category 4)
H333	Acute toxicity,inhalation (Category 5)
H334	Sensitisation, respiratory (Category 1)
H335	Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3)
H336	Specific target organ toxicity,single exposure; Narcoticeffects (Category 3)
H340	Germ cell mutagenicity (Category 1A, 1B)
H341	Germ cell mutagenicity (Category 2)
H350	Carcinogenicity (Category 1A, 1B)
H351	Carcinogenicity (Category 2)
H360	Reproductive toxicity (Category 1A, 1B)
H361	Reproductive toxicity (Category 2)
H362	Reproductive toxicity, effects on or via lactation (Additional category)
H370	Specific target organ toxicity, single exposure (Category 1)
H371	Specific target organ toxicity, single exposure (Category 2)
H372	Specific target organ toxicity, repeated exposure (Category 1)
H373	Specific target organ toxicity, repeated exposure (Category 2)

H400	Hazardous to the aquatic environment, acute hazard (Category 1)
H401	Hazardous to the aquatic environment, acute hazard (Category 2)
H402	Hazardous to the aquatic environment, acute hazard (Category 3)
H410	Hazardous to the aquatic environment, long-term hazard(Category 1)
H411	Hazardous to the aquatic environment, long-term hazard (Category 2)
H412	Hazardous to the aquatic environment, long-term hazard (Category 3)
H413	Hazardous to the aquatic environment, long-term hazard (Category 4)
H420	Hazardous to the ozone layer (Category 1)